FAR2

Across TCGA patient cohorts, FAR2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAR2-associated genes across cancer lineages are Caspase-7-cleavedD198, INPP4B, and JNK_pT183_Y185. Each is linked with FAR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FAR2-to-partner and partner-to-FAR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FAR2-low versus FAR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAR2→partner) and Y-score (partner→FAR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.678	+1.604	.004	.041	3	2
UCEC	INPP4B →	-0.277	-2.999	.033	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.173	-1.807	.010	.025	3	1
UCEC	Ku80 →	+0.282	+3.100	.002	<.001	3	1
UCEC	MAPK_pT202_Y204 →	-0.510	-3.584	.006	.002	3	1
UCEC	MEK1_p_S217_S221 →	-0.231	-2.000	.035	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Caspase-7-cleavedD198 by FAR2 expression — UCEC

Explore this box plot interactively →