Across TCGA patient cohorts, FANCM mutation is significantly associated with the RNA expression of many other genes, with 5,283 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FANCM-associated genes across cancer lineages are CDCA2, COX7A2, and CDKN3. Each is linked with FANCM in more than 5 cancer types. Because this analysis shows association rather than direction, both FANCM-to-partner and partner-to-FANCM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCM→partner) and Y-score (partner→FANCM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CDCA2 →	+0.780	+2.713	<.001	.003	3	5
LUSC	COX7A2 →	+0.604	+3.954	<.001	<.001	2	6
LUAD	CDKN3 →	+0.897	+2.834	<.001	.001	3	5
LUAD	NCAPG →	+0.812	+3.345	.001	.005	3	5
SKCM	EIF2S1 →	+0.513	+3.725	<.001	<.001	3	5
LUAD	PBK →	+0.920	+3.727	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,283 associations by consensus.

Exploration

FANCM survival (RNA) · tumor vs normal (RNA) · all FANCM data types