Across TCGA patient cohorts, FANCM mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FANCM-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and Cyclin-B1. Each is linked with FANCM in more than 5 cancer types. Because this analysis shows association rather than direction, both FANCM-to-partner and partner-to-FANCM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCM→partner) and Y-score (partner→FANCM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.370	+3.708	<.001	<.001	3	6
COAD	ASNS →	+0.715	+3.459	<.001	.005	3	5
COAD	Cyclin-B1 →	+0.499	+2.593	.029	.006	3	5
UCEC	STAT3_pY705 →	-0.325	-1.530	<.001	.002	3	4
SKCM	GAPDH →	+0.459	+2.459	.032	.017	3	4
STAD	eIF4E →	+0.231	+3.321	.006	.010	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

Exploration

FANCM survival (RNA) · tumor vs normal (RNA) · all FANCM data types