Across TCGA cell cohorts, FANCM mutation is significantly associated with the RNA expression of many other genes, with 1,229 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FANCM-associated genes across cancer lineages are C11orf95, ODF3, and CCL4. Each is linked with FANCM in more than 2 cancer types. Because this analysis shows association rather than direction, both FANCM-to-partner and partner-to-FANCM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCM→partner) and Y-score (partner→FANCM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C11orf95 →	+0.584	+3.074	.002	.008	3	3
LUNG_NSCLC_LUSC	ODF3 →	+0.037	+3.569	<.001	.003	3	2
BREAST	CCL4 →	+0.167	+3.971	.005	<.001	3	2
STOMACH	USP50 →	+0.165	+3.691	.009	.002	3	2
STOMACH	SERPINB4 →	+0.660	+3.459	.007	.006	3	2
STOMACH	CECR2 →	+0.635	+3.350	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,229 associations by consensus.

Exploration

FANCM survival (RNA) · tumor vs normal (RNA) · all FANCM data types