FANCL

Across TCGA patient cohorts, FANCL RNA expression is significantly associated with the protein abundance of many other proteins, with 18,369 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FANCL-associated proteins across cancer lineages are MSH2, RRBP1, and CHAMP1. Each is linked with FANCL in more than 6 cancer types. Because this analysis shows association rather than direction, both FANCL-to-partner and partner-to-FANCL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FANCL versus MSH2 in LSCC, with a Pearson correlation of 0.69.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCL→partner) and Y-score (partner→FANCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MSH2 →	+0.605	+0.732	<.001	<.001	3	7
BRCA	RRBP1 →	-0.353	-0.459	<.001	<.001	3	6
LSCC	CHAMP1 →	+0.355	+0.848	<.001	<.001	3	6
GBM	VRK2 →	+0.615	+0.403	.004	.007	3	6
LSCC	ZNF638 →	+0.294	+0.704	<.001	<.001	3	6
LSCC	MSH6 →	+0.710	+0.747	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,369 associations by consensus.

FANCL vs MSH2 — LSCC

Explore this scatter interactively →