FANCL

Across TCGA patient cohorts, FANCL protein abundance is significantly associated with the RNA expression of many other genes, with 2,471 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible FANCL-associated genes across cancer lineages are FHL5, CASQ2, and KREMEN2. Each is linked with FANCL in more than 1 cancer types. Because this analysis shows association rather than direction, both FANCL-to-partner and partner-to-FANCL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FANCL versus FHL5 in GBM, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCL→partner) and Y-score (partner→FANCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FHL5 →	+1.318	+0.981	<.001	.002	3	2
LUAD	CASQ2 →	+0.795	+0.940	<.001	<.001	3	2
LSCC	KREMEN2 →	-0.846	-0.605	.009	<.001	3	2
LSCC	MYH11 →	+1.590	+0.801	.005	.002	3	2
LUAD	DUSP26 →	+0.570	+1.162	.001	<.001	3	2
GBM	PDE5A →	+0.913	+1.057	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,471 associations by consensus.

FANCL vs FHL5 — GBM

Explore this scatter interactively →