FANCL

Across TCGA patient cohorts, FANCL mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FANCL-associated genes across cancer lineages are A-Raf_pS299, ERK2, and FoxM1. Each is linked with FANCL in more than 1 cancer types. Because this analysis shows association rather than direction, both FANCL-to-partner and partner-to-FANCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by FANCL-low versus FANCL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCL→partner) and Y-score (partner→FANCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.164	-2.584	.001	.010	3	1
UCEC	ERK2 →	+0.301	+4.000	<.001	<.001	3	1
UCEC	FoxM1 →	+0.250	+2.222	.022	.011	3	1
UCEC	GATA6 →	-0.133	-2.985	.043	.034	3	1
UCEC	HER2 →	+0.433	+2.000	.024	.030	3	1
UCEC	ACVRL1 →	-0.153	-2.986	.008	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

A-Raf_pS299 by FANCL expression — UCEC

Explore this box plot interactively →