FANCL

Across TCGA cell cohorts, FANCL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,721 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible FANCL-associated GO terms across cancer lineages are Centrosome cycle, DNA-templated DNA replication maintenance of fidelity, and Mitotic cell cycle checkpoint signaling. Each is linked with FANCL in more than 16 cancer types. Because this analysis shows association rather than direction, both FANCL-to-partner and partner-to-FANCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centrosome cycle grouped by FANCL-low versus FANCL-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCL→partner) and Y-score (partner→FANCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Centrosome cycle →	+0.078	+0.886	<.001	<.001	3	17
BONE	DNA-templated DNA replication maintenance of fidelity →	+0.111	+0.726	.003	.003	3	15
UPPER_AERODIGESTIVE_TRACT	Mitotic cell cycle checkpoint signaling →	+0.098	+1.369	<.001	<.001	3	15
LUNG_SCLC	Negative regulation of gene expression via chromosomal CpG island methylation →	+0.145	+0.678	<.001	.008	3	14
BLOOD_Myeloma	DNA-templated DNA replication →	+0.147	+1.072	<.001	.001	2	15
SOFT_TISSUE	Centriole replication →	+0.099	+1.064	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,721 associations by consensus.

Centrosome cycle by FANCL expression — LUNG_SCLC

Explore this box plot interactively →