FANCL

Across TCGA cell cohorts, FANCL mutation is significantly associated with the drug of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FANCL-associated genes across cancer lineages are Acetalax, OF-1, and GSK2110183B. Each is linked with FANCL in more than 1 cancer types. Because this analysis shows association rather than direction, both FANCL-to-partner and partner-to-FANCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetalax grouped by FANCL-low versus FANCL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCL→partner) and Y-score (partner→FANCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Acetalax →	+0.714	+2.649	.030	.046	3	1
LARGE_INTESTINE	OF-1 →	+0.297	+2.646	.040	.047	3	1
LARGE_INTESTINE	GSK2110183B →	+0.626	+2.649	.040	.046	2	1
LARGE_INTESTINE	AZD5991 →	+0.898	+2.649	.018	.046	1	1
LARGE_INTESTINE	TAF1_5496 →	+0.503	+2.777	.024	.038	1	1
LARGE_INTESTINE	AT7867 →	+0.484	+2.652	.045	.045	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Acetalax by FANCL expression — LARGE_INTESTINE

Explore this box plot interactively →