FANCI

Across TCGA pan-cancer cohorts, FANCI mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FANCI data layer compared with 31 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher FANCI mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FANCI expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

COAD, LUAD, and LSCC are the cancer types where FANCI mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.912	1.000	.019	30	view →
LUAD	DFS	Median	III,IV	0.981	0.538	.001	23	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.579	.003	16	view →
PDAC	OS	Quartile	All	0.771	0.976	.027	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FANCI–COAD (DFS)

Open the COAD breakdown →