FANCI

Across TCGA patient cohorts, FANCI protein abundance is significantly associated with the RNA expression of many other genes, with 18,605 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FANCI-associated genes across cancer lineages are TEDC2, TK1, and UBE2T. Each is linked with FANCI in more than 8 cancer types. Because this analysis shows association rather than direction, both FANCI-to-partner and partner-to-FANCI results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FANCI versus TEDC2 in LUAD, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCI→partner) and Y-score (partner→FANCI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TEDC2 →	+1.021	+0.627	<.001	<.001	3	9
UCEC	TK1 →	+1.224	+0.706	<.001	<.001	3	9
UCEC	UBE2T →	+1.324	+0.420	<.001	<.001	3	9
BRCA	CDC45 →	+1.267	+0.691	<.001	<.001	3	9
LSCC	EZH2 →	+1.017	+0.749	<.001	<.001	3	8
OV	HELLS →	+1.004	+0.622	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,605 associations by consensus.

FANCI vs TEDC2 — LUAD

Explore this scatter interactively →