FANCI

Across TCGA patient cohorts, FANCI mutation is significantly associated with the RNA expression of many other genes, with 5,014 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FANCI-associated genes across cancer lineages are RN7SL578P, MIR7976, and PLEKHJ1. Each is linked with FANCI in more than 2 cancer types. Because this analysis shows association rather than direction, both FANCI-to-partner and partner-to-FANCI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL578P grouped by FANCI-low versus FANCI-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCI→partner) and Y-score (partner→FANCI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RN7SL578P →	+0.172	+5.039	<.001	.008	3	3
CESC	MIR7976 →	+0.915	+4.269	<.001	.003	3	3
UCEC	PLEKHJ1 →	+0.687	+2.470	<.001	<.001	3	3
UCEC	PLEKHA8 →	+0.409	+3.201	<.001	<.001	3	3
UCEC	PARP2 →	+0.472	+1.954	<.001	<.001	3	3
UCEC	LSM4 →	+0.367	+2.192	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,014 associations by consensus.

RN7SL578P by FANCI expression — READ

Explore this box plot interactively →