FANCI

Across TCGA patient cohorts, FANCI mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FANCI-associated genes across cancer lineages are Annexin-1, ATM, and PRDX1. Each is linked with FANCI in more than 2 cancer types. Because this analysis shows association rather than direction, both FANCI-to-partner and partner-to-FANCI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by FANCI-low versus FANCI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCI→partner) and Y-score (partner→FANCI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.433	+1.522	.007	.017	3	3
UCEC	ATM →	-0.520	-3.893	<.001	<.001	3	3
SKCM	PRDX1 →	+0.406	+3.000	.007	.035	3	2
COAD	Caspase-7-cleavedD198 →	+1.742	+2.815	<.001	.036	3	2
UCEC	ERK2 →	+0.145	+2.000	.014	.029	3	2
UCEC	FASN →	+0.392	+2.169	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

Annexin-1 by FANCI expression — UCEC

Explore this box plot interactively →