FANCI

Across TCGA cell cohorts, FANCI RNA expression is significantly associated with the go_rna of many other GO terms, with 4,626 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FANCI-associated GO terms across cancer lineages are DNA replication checkpoint signaling, Sister chromatid segregation, and Positive regulation of cell cycle process. Each is linked with FANCI in more than 19 cancer types. Because this analysis shows association rather than direction, both FANCI-to-partner and partner-to-FANCI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication checkpoint signaling grouped by FANCI-low versus FANCI-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCI→partner) and Y-score (partner→FANCI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication checkpoint signaling →	+0.192	+1.262	.002	.007	3	20
OESOPHAGUS	Sister chromatid segregation →	+0.134	+1.256	<.001	.001	3	20
UPPER_AERODIGESTIVE_TRACT	Positive regulation of cell cycle process →	+0.098	+1.803	<.001	<.001	3	20
OVARY	Regulation of G2/M transition of mitotic cell cycle →	+0.088	+1.275	<.001	<.001	3	20
OVARY	Negative regulation of G2/M transition of mitotic cell cycle →	+0.081	+1.132	<.001	<.001	3	20
OESOPHAGUS	Mitotic nuclear division →	+0.129	+1.225	.001	.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,626 associations by consensus.

DNA replication checkpoint signaling by FANCI expression — BONE

Explore this box plot interactively →