FANCI

Across TCGA cell cohorts, FANCI mutation is significantly associated with the RNA expression of many other genes, with 324 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FANCI-associated genes across cancer lineages are OR13D1, SKOR2, and ZIM3. Each is linked with FANCI in more than 1 cancer types. Because this analysis shows association rather than direction, both FANCI-to-partner and partner-to-FANCI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13D1 grouped by FANCI-low versus FANCI-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCI→partner) and Y-score (partner→FANCI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR13D1 →	+0.019	+3.345	<.001	.007	3	2
KIDNEY	SKOR2 →	+0.016	+5.000	<.001	.005	3	1
OESOPHAGUS	ZIM3 →	+0.006	+4.906	<.001	.006	3	1
BREAST	KRTAP13-2 →	+0.120	+3.672	<.001	.006	3	1
OVARY	VCY →	+0.297	+4.228	<.001	.006	3	1
LUNG_NSCLC_LUAD	RETN →	+0.095	+4.212	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 324 associations by consensus.

OR13D1 by FANCI expression — SKIN

Explore this box plot interactively →