Across TCGA patient cohorts, FANCG mutation is significantly associated with the RNA expression of many other genes, with 335 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FANCG-associated genes across cancer lineages are RN7SKP60, RNU6-290P, and MIR6839. Each is linked with FANCG in more than 2 cancer types. Because this analysis shows association rather than direction, both FANCG-to-partner and partner-to-FANCG results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCG→partner) and Y-score (partner→FANCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP60 →	+0.099	+4.147	<.001	.008	3	3
SKCM	RNU6-290P →	+0.169	+4.147	<.001	.008	3	2
UCEC	MIR6839 →	+0.237	+2.977	<.001	.003	3	1
UCEC	TRBV11-3 →	+0.446	+2.280	<.001	.006	3	1
UCEC	RNA5SP411 →	+1.058	+2.393	.001	.002	3	1
SKCM	LATS2-AS1 →	+0.083	+3.126	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 335 associations by consensus.

Exploration

FANCG survival (RNA) · tumor vs normal (RNA) · all FANCG data types