Across TCGA patient cohorts, FANCG mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FANCG-associated genes across cancer lineages are ERK2, IGFBP2, and JNK2. Each is linked with FANCG in more than 1 cancer types. Because this analysis shows association rather than direction, both FANCG-to-partner and partner-to-FANCG results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCG→partner) and Y-score (partner→FANCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.201	+2.459	.031	.020	3	1
UCEC	IGFBP2 →	-0.956	-2.999	.002	.035	3	1
UCEC	JNK2 →	+0.190	+2.459	.048	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.620	+3.189	.030	.010	3	1
UCEC	VHL →	-0.934	-3.169	.004	.019	2	1
UCEC	Chk2 →	-0.325	-3.584	.004	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

FANCG survival (RNA) · tumor vs normal (RNA) · all FANCG data types