Across TCGA cell cohorts, FANCF mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FANCF-associated genes across cancer lineages are GML, MMP27, and AWAT2. Each is linked with FANCF in more than 1 cancer types. Because this analysis shows association rather than direction, both FANCF-to-partner and partner-to-FANCF results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCF→partner) and Y-score (partner→FANCF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.099	+4.152	<.001	.009	3	1
BLOOD_Leukemia	MMP27 →	+0.019	+4.969	<.001	.003	3	1
BLOOD_Leukemia	AWAT2 →	+0.010	+4.705	.004	.003	3	1
BLOOD_Leukemia	MCHR2 →	+0.034	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TXNDC8 →	+0.012	+5.569	<.001	.001	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.123	+6.124	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

FANCF survival (RNA) · tumor vs normal (RNA) · all FANCF data types