FANCD2

Across TCGA cell cohorts, FANCD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,595 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible FANCD2-associated GO terms across cancer lineages are Nuclear division, Replication fork processing, and Cell cycle DNA replication. Each is linked with FANCD2 in more than 19 cancer types. Because this analysis shows association rather than direction, both FANCD2-to-partner and partner-to-FANCD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear division grouped by FANCD2-low versus FANCD2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCD2→partner) and Y-score (partner→FANCD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Nuclear division →	+0.120	+1.690	.002	.002	3	20
PANCREAS	Replication fork processing →	+0.114	+1.248	<.001	<.001	3	20
BONE	Cell cycle DNA replication →	+0.160	+1.456	.001	<.001	3	20
PANCREAS	DNA-templated DNA replication maintenance of fidelity →	+0.117	+1.186	<.001	<.001	3	20
OESOPHAGUS	DNA replication →	+0.115	+1.335	.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.147	+1.876	<.001	.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,595 associations by consensus.

Nuclear division by FANCD2 expression — BONE

Explore this box plot interactively →