FANCD2

Across TCGA cell cohorts, FANCD2 mutation is significantly associated with the RNA expression of many other genes, with 144 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FANCD2-associated genes across cancer lineages are TCF23, DNAH8, and GFRA4. Each is linked with FANCD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FANCD2-to-partner and partner-to-FANCD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCF23 grouped by FANCD2-low versus FANCD2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCD2→partner) and Y-score (partner→FANCD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TCF23 →	+0.004	+3.632	<.001	.003	3	2
SOFT_TISSUE	DNAH8 →	+0.307	+3.679	.002	.005	3	1
SOFT_TISSUE	GFRA4 →	+0.013	+3.584	.002	.004	3	1
SOFT_TISSUE	OR4X2 →	+0.021	+4.369	<.001	<.001	3	1
SOFT_TISSUE	OR52A1 →	+0.014	+3.584	<.001	.004	3	1
SOFT_TISSUE	OR8G1 →	+0.053	+3.297	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 144 associations by consensus.

TCF23 by FANCD2 expression — SKIN

Explore this box plot interactively →