FANCD2

Across TCGA cell cohorts, FANCD2 mutation is significantly associated with the mutation status of many other genes, with 3,511 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FANCD2-associated genes across cancer lineages are C5, INO80D, and TICRR. Each is linked with FANCD2 in more than 4 cancer types. Because this analysis shows association rather than direction, both FANCD2-to-partner and partner-to-FANCD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5 grouped by FANCD2-low versus FANCD2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCD2→partner) and Y-score (partner→FANCD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	C5 →	+4.095	+4.095	.002	.002	1	5
SOFT_TISSUE	INO80D →	+4.192	+3.852	<.001	<.001	1	5
SOFT_TISSUE	TICRR →	+3.777	+3.307	.005	.005	1	5
BLOOD_Lymphoma	CRYBG3 →	+4.554	+4.247	.001	.001	1	4
SKIN	RASGRF1 →	+2.548	+2.641	.008	.008	1	4
BLOOD_Leukemia	SPEN →	+2.053	+2.535	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,511 associations by consensus.

C5 by FANCD2 expression — BREAST

Explore this box plot interactively →