FANCC

Across TCGA patient cohorts, FANCC RNA expression is significantly associated with the protein abundance of many other proteins, with 19,780 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FANCC-associated proteins across cancer lineages are SPIN1, WDR5, and ANP32B. Each is linked with FANCC in more than 7 cancer types. Because this analysis shows association rather than direction, both FANCC-to-partner and partner-to-FANCC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FANCC versus SPIN1 in LSCC, with a Pearson correlation of 0.68.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCC→partner) and Y-score (partner→FANCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPIN1 →	+0.376	+0.690	<.001	<.001	3	8
LSCC	WDR5 →	+0.286	+0.705	<.001	<.001	3	7
BRCA	ANP32B →	+0.386	+0.469	<.001	<.001	3	7
COAD	EHMT1 →	+0.463	+0.632	<.001	<.001	3	7
HNSC	HNRNPU →	+0.325	+0.781	<.001	<.001	3	7
OV	PHF2 →	+0.355	+0.620	.002	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,780 associations by consensus.

FANCC vs SPIN1 — LSCC

Explore this scatter interactively →