FANCC

Across TCGA patient cohorts, FANCC protein abundance is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible FANCC-associated genes across cancer lineages are HOXA7, KERA, and PCSK7. Each is linked with FANCC in more than 1 cancer types. Because this analysis shows association rather than direction, both FANCC-to-partner and partner-to-FANCC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FANCC versus HOXA7 in HNSC, with a Pearson correlation of -0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCC→partner) and Y-score (partner→FANCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HOXA7 →	-1.660	-0.717	.004	.009	3	1
HNSC	KERA →	+0.587	+0.636	<.001	.002	3	1
HNSC	PCSK7 →	-0.845	-0.647	.003	.002	3	1
HNSC	LRRC8C →	+0.733	+0.636	.001	.002	3	1
HNSC	AQP11 →	-1.719	-0.817	.007	.002	3	1
HNSC	POTEF →	+3.075	+0.636	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

FANCC vs HOXA7 — HNSC

Explore this scatter interactively →