FANCC

Across TCGA patient cohorts, FANCC mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FANCC-associated genes across cancer lineages are p62 Lck ligand, Rab25, and EGFR_pY1068. Each is linked with FANCC in more than 1 cancer types. Because this analysis shows association rather than direction, both FANCC-to-partner and partner-to-FANCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by FANCC-low versus FANCC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCC→partner) and Y-score (partner→FANCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.253	+2.469	.042	.010	3	2
UCEC	Rab25 →	-0.260	-2.459	.041	.019	3	2
UCEC	EGFR_pY1068 →	-0.192	-1.700	.046	.042	3	1
UCEC	Fibronectin →	-0.294	-1.896	.020	.015	3	1
UCEC	FoxM1 →	+0.226	+1.678	.023	.023	3	1
UCEC	IGFBP2 →	-0.967	-3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

p62 Lck ligand by FANCC expression — UCEC

Explore this box plot interactively →