FANCC

Across TCGA cell cohorts, FANCC mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FANCC-associated genes across cancer lineages are GFRA4, INSL5, and ABCG8. Each is linked with FANCC in more than 1 cancer types. Because this analysis shows association rather than direction, both FANCC-to-partner and partner-to-FANCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by FANCC-low versus FANCC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCC→partner) and Y-score (partner→FANCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GFRA4 →	+0.019	+3.345	.001	.007	3	1
LARGE_INTESTINE	INSL5 →	+0.376	+3.626	<.001	.006	3	1
LARGE_INTESTINE	ABCG8 →	+0.377	+3.453	<.001	.009	2	1
LARGE_INTESTINE	IL20 →	+0.293	+3.984	<.001	.001	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GFRA4 by FANCC expression — LARGE_INTESTINE

Explore this box plot interactively →