FANCB

Across TCGA patient cohorts, FANCB mutation is significantly associated with the RNA expression of many other genes, with 3,401 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FANCB-associated genes across cancer lineages are RN7SKP169, MIR6766, and HIRA. Each is linked with FANCB in more than 2 cancer types. Because this analysis shows association rather than direction, both FANCB-to-partner and partner-to-FANCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP169 grouped by FANCB-low versus FANCB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCB→partner) and Y-score (partner→FANCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SKP169 →	+0.139	+4.392	.003	.006	3	3
BRCA	MIR6766 →	+0.501	+4.575	<.001	.009	3	2
UCEC	HIRA →	+0.478	+1.653	<.001	<.001	3	2
UCEC	SNU13 →	+0.239	+1.915	.002	<.001	3	2
UCEC	TBL1X →	+0.462	+1.632	.001	<.001	3	2
UCEC	PGK1 →	+0.655	+1.830	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,401 associations by consensus.

RN7SKP169 by FANCB expression — COAD

Explore this box plot interactively →