FANCB

Across TCGA cell cohorts, FANCB RNA expression is significantly associated with the go_rna of many other GO terms, with 5,014 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FANCB-associated GO terms across cancer lineages are Regulation of cell cycle checkpoint, Positive regulation of mitotic cell cycle phase transition, and Regulation of metaphase/anaphase transition of cell cycle. Each is linked with FANCB in more than 19 cancer types. Because this analysis shows association rather than direction, both FANCB-to-partner and partner-to-FANCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell cycle checkpoint grouped by FANCB-low versus FANCB-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCB→partner) and Y-score (partner→FANCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of cell cycle checkpoint →	+0.176	+1.239	<.001	<.001	3	20
OESOPHAGUS	Positive regulation of mitotic cell cycle phase transition →	+0.162	+1.002	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase/anaphase transition of cell cycle →	+0.144	+1.224	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation →	+0.220	+1.078	<.001	<.001	3	20
OESOPHAGUS	Nuclear division →	+0.127	+1.337	<.001	<.001	3	20
KIDNEY	Regulation of mitotic metaphase/anaphase transition →	+0.147	+1.046	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,014 associations by consensus.

Regulation of cell cycle checkpoint by FANCB expression — OESOPHAGUS

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