Across TCGA pan-cancer cohorts, FANCA mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of FANCA’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FANCA mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FANCA is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

HNSC, LSCC, and PDAC are the cancer types where FANCA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FANCA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	−0.301	.020	5	view →
LSCC	All	All	+0.827	<.001	4	view →
PDAC	All	All	−0.340	.033	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: FANCA RNA expression & survival · all FANCA data types