Across TCGA patient cohorts, FANCA mutation is significantly associated with the RNA expression of many other genes, with 3,894 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FANCA-associated genes across cancer lineages are TMEM170A, SNRNP40, and MCM10. Each is linked with FANCA in more than 3 cancer types. Because this analysis shows association rather than direction, both FANCA-to-partner and partner-to-FANCA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCA→partner) and Y-score (partner→FANCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM170A →	+0.406	+2.641	.001	<.001	3	4
UCEC	SNRNP40 →	+0.427	+1.732	.002	.002	3	4
SKCM	MCM10 →	+0.912	+3.604	<.001	.001	3	4
UCEC	ORC6 →	+0.451	+1.642	.001	<.001	3	4
UCEC	GNPNAT1 →	+0.479	+2.233	.001	<.001	3	4
UCEC	LARP1B →	+0.497	+1.685	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,894 associations by consensus.

Exploration

FANCA survival (RNA) · tumor vs normal (RNA) · all FANCA data types