Across TCGA patient cohorts, FANCA mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FANCA-associated genes across cancer lineages are eEF2, ERK2, and ASNS. Each is linked with FANCA in more than 3 cancer types. Because this analysis shows association rather than direction, both FANCA-to-partner and partner-to-FANCA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCA→partner) and Y-score (partner→FANCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eEF2 →	+0.440	+3.169	<.001	.018	3	3
COAD	ERK2 →	+0.210	+3.000	.012	.034	3	3
COAD	ASNS →	+0.439	+3.000	.010	.035	3	3
UCEC	Shc_pY317 →	-0.162	-2.137	<.001	<.001	3	3
UCEC	ATM →	-0.463	-2.893	<.001	.001	3	3
STAD	GAPDH →	+0.639	+3.000	<.001	.036	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Exploration

FANCA survival (RNA) · tumor vs normal (RNA) · all FANCA data types