Across TCGA cell cohorts, FANCA RNA expression is significantly associated with the go_rna of many other GO terms, with 5,550 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible FANCA-associated GO terms across cancer lineages are Positive regulation of DNA-directed DNA polymerase activity, Replication fork processing, and Nuclear DNA replication. Each is linked with FANCA in more than 19 cancer types. Because this analysis shows association rather than direction, both FANCA-to-partner and partner-to-FANCA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCA→partner) and Y-score (partner→FANCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of DNA-directed DNA polymerase activity →	+0.195	+1.304	<.001	<.001	3	20
OESOPHAGUS	Replication fork processing →	+0.104	+0.970	<.001	<.001	3	20
BONE	Nuclear DNA replication →	+0.172	+1.626	.001	<.001	3	20
BONE	Cell cycle DNA replication →	+0.165	+1.520	.001	.002	3	20
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication maintenance of fidelity →	+0.128	+1.424	<.001	<.001	3	20
BONE	DNA strand elongation involved in DNA replication →	+0.210	+2.005	.002	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,550 associations by consensus.

Exploration

FANCA survival (RNA) · tumor vs normal (RNA) · all FANCA data types