Across TCGA cell cohorts, FANCA mutation is significantly associated with the RNA expression of many other genes, with 1,992 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FANCA-associated genes across cancer lineages are FCN2, GPR152, and EIF3L. Each is linked with FANCA in more than 1 cancer types. Because this analysis shows association rather than direction, both FANCA-to-partner and partner-to-FANCA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCA→partner) and Y-score (partner→FANCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FCN2 →	+0.022	+3.129	.006	.002	3	2
CNS	GPR152 →	+0.044	+2.736	.005	.006	3	2
LARGE_INTESTINE	EIF3L →	+0.491	+2.652	<.001	.001	3	2
LARGE_INTESTINE	CBX7 →	+0.953	+3.409	<.001	<.001	3	2
LARGE_INTESTINE	KCTD17 →	+0.778	+3.321	.004	.003	3	2
LARGE_INTESTINE	METTL4 →	+0.648	+2.652	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,992 associations by consensus.

Exploration

FANCA survival (RNA) · tumor vs normal (RNA) · all FANCA data types