Across TCGA patient cohorts, FAN1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,610 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FAN1-associated genes across cancer lineages are FCGR3B, CXCR1, and CXCR2. Each is linked with FAN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FAN1-to-partner and partner-to-FAN1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAN1→partner) and Y-score (partner→FAN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FCGR3B →	+1.880	+1.607	<.001	.001	3	3
UCEC	CXCR1 →	+1.397	+1.894	.003	.003	3	3
UCEC	CXCR2 →	+1.377	+2.260	.005	<.001	3	3
BRCA	MRPL37 →	+0.628	+1.741	.005	<.001	3	2
OV	ADGRE2 →	+0.628	+1.836	.003	.001	3	2
BRCA	TUBBP1 →	+1.601	+1.408	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,610 associations by consensus.

Exploration

FAN1 survival (RNA) · tumor vs normal (RNA) · all FAN1 data types