FAN1

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, FAN1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAN1-associated genes across cancer lineages are ATM, PDCD4, and EGFR_pY1068. Each is linked with FAN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FAN1-to-partner and partner-to-FAN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAN1→partner) and Y-score (partner→FAN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECATM →-0.629-3.807<.001<.00133
UCECPDCD4 →-0.433-1.440.007.02432
UCECEGFR_pY1068 →-0.247-1.440.004.02432
UCECINPP4B →-0.397-3.087<.001<.00132
UCECMEK1 →+0.251+1.807.048.02532
UCECmTOR_pS2448 →-0.128-1.736.013.00732
Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Exploration