Across TCGA cell cohorts, FAN1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FAN1-associated genes across cancer lineages are MAGEB4, OLIG1, and PRR23A. Each is linked with FAN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FAN1-to-partner and partner-to-FAN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAN1→partner) and Y-score (partner→FAN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MAGEB4 →	+0.006	+5.662	<.001	.002	3	2
BONE	OLIG1 →	+1.853	+4.000	<.001	.008	3	1
BONE	PRR23A →	+0.058	+4.672	<.001	.001	3	1
BONE	OOSP3 →	+0.041	+4.000	<.001	.008	3	1
BLOOD_Leukemia	TMEM82 →	+0.006	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	KLK9 →	+0.026	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

FAN1 survival (RNA) · tumor vs normal (RNA) · all FAN1 data types