Across TCGA pan-cancer cohorts, FAM9C Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated FAM9C data layer compared with 17 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher FAM9C Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FAM9C expression acts as an unfavorable survival marker.

SKCM and PRAD are the cancer types where FAM9C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	II,III,IV	0.373	0.739	.001	20	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: FAM9C tumor-vs-normal RNA expression · all FAM9C data types