Across TCGA patient cohorts, FAM9A mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM9A-associated genes across cancer lineages are S6_pS240_S244, Caspase-8, and ER-alpha_pS118. Each is linked with FAM9A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM9A-to-partner and partner-to-FAM9A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM9A→partner) and Y-score (partner→FAM9A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.334	+2.321	.009	<.001	3	2
UCEC	Caspase-8 →	-0.196	-1.973	.013	.008	3	2
UCEC	ER-alpha_pS118 →	-0.250	-1.836	.027	.001	3	1
UCEC	ACC1 →	+0.231	+1.584	.044	.005	3	1
UCEC	HER3 →	-0.182	-1.124	.035	.041	3	1
UCEC	Heregulin →	-0.096	-2.222	.013	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

FAM9A survival (RNA) · tumor vs normal (RNA) · all FAM9A data types