Across TCGA pan-cancer cohorts, FAM99A RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FAM99A’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where FAM99A RNA is repressed in tumor relative to normal tissue. In most cancer types FAM99A is over-expressed in tumor, although a few such as LIHC and CHOL show the opposite, repressed pattern.

LIHC, CHOL, and KICH are the cancer types where FAM99A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM99A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	II,III,IV	−3.899	<.001	8	view →
CHOL	Female	All	−5.690	<.001	5	view →
KICH	All	All	−0.012	.003	3	view →
UCEC	All	All	+0.013	.049	2	view →
COAD	All	All	+0.026	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: FAM99A RNA expression & survival · all FAM99A data types