FAM98B

Across TCGA patient cohorts, FAM98B mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM98B-associated genes across cancer lineages are EGFR_pY1068, ERK2, and HER3. Each is linked with FAM98B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM98B-to-partner and partner-to-FAM98B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FAM98B-low versus FAM98B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM98B→partner) and Y-score (partner→FAM98B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.240	-2.087	.012	.005	3	1
UCEC	ERK2 →	+0.232	+2.222	.001	.009	3	1
UCEC	HER3 →	+0.390	+1.750	<.001	.049	3	1
UCEC	JNK2 →	+0.262	+2.087	<.001	.005	3	1
UCEC	Ku80 →	+0.299	+2.598	<.001	<.001	3	1
UCEC	MAPK_pT202_Y204 →	-0.434	-2.115	.016	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR_pY1068 by FAM98B expression — UCEC

Explore this box plot interactively →