FAM98A

Across TCGA pan-cancer cohorts, FAM98A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FAM98A data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FAM98A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM98A expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LSCC, and GBM are the cancer types where FAM98A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.862	0.686	.007	26	view →
LSCC	DFS	Median	III,IV	0.358	0.847	.002	15	view →
GBM	OS	Quartile	All	0.302	0.750	.004	7	view →
PDAC	OS	Tertile	IV	0.425	0.962	.024	6	view →
LUAD	OS	Tertile	All	0.998	0.865	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FAM98A–HNSC (DFS)

Open the HNSC breakdown →