Across TCGA pan-cancer cohorts, FAM96AP1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of FAM96AP1’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where FAM96AP1 RNA is repressed in tumor relative to normal tissue. In most cancer types FAM96AP1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where FAM96AP1 tumor–normal differential expression is most reproducible.