FAM91A1

Across TCGA pan-cancer cohorts, FAM91A1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FAM91A1 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher FAM91A1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM91A1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where FAM91A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.928	0.105	.006	17	view →
HNSC	DFS	Quartile	All	0.215	0.810	.014	16	view →
PDAC	DFS	Tertile	IV	0.199	0.934	.024	9	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.860	.014	5	view →
GBM	DFS	Quartile	All	0.638	0.813	.027	4	view →
LUAD	OS	Tertile	III,IV	0.845	0.322	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FAM91A1–CCRCC (DFS)

Open the CCRCC breakdown →