FAM91A1

Across TCGA patient cohorts, FAM91A1 mutation is significantly associated with the RNA expression of many other genes, with 4,481 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM91A1-associated genes across cancer lineages are MTA2, SDHA, and SNW1. Each is linked with FAM91A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM91A1-to-partner and partner-to-FAM91A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTA2 grouped by FAM91A1-low versus FAM91A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM91A1→partner) and Y-score (partner→FAM91A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTA2 →	+0.380	+2.421	<.001	<.001	3	3
UCEC	SDHA →	+0.393	+1.625	.002	.002	3	3
UCEC	SNW1 →	+0.328	+1.786	.005	<.001	3	3
COAD	GBE1 →	+0.586	+3.236	.001	.008	3	3
UCEC	RPA2 →	+0.432	+1.584	<.001	<.001	3	3
UCEC	EFL1 →	+0.504	+1.595	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,481 associations by consensus.

MTA2 by FAM91A1 expression — UCEC

Explore this box plot interactively →