FAM91A1

Across TCGA patient cohorts, FAM91A1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM91A1-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and MEK1. Each is linked with FAM91A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM91A1-to-partner and partner-to-FAM91A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FAM91A1-low versus FAM91A1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM91A1→partner) and Y-score (partner→FAM91A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.591	-3.161	.002	.019	3	3
COAD	Caspase-7-cleavedD198 →	+1.501	+3.178	<.001	.010	3	3
UCEC	MEK1 →	+0.491	+2.722	<.001	<.001	3	2
COAD	PKC-b-II_pS660 →	-0.445	-3.161	.010	.019	3	2
UCEC	Cyclin-B1 →	+0.654	+2.146	<.001	<.001	3	2
UCEC	eIF4E →	+0.221	+2.415	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

ATM by FAM91A1 expression — COAD

Explore this box plot interactively →