FAM91A1

Across TCGA cell cohorts, FAM91A1 mutation is significantly associated with the mutation status of many other genes, with 2,579 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM91A1-associated genes across cancer lineages are FN1, GABRA1, and FBXO7. Each is linked with FAM91A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FAM91A1-to-partner and partner-to-FAM91A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FN1 grouped by FAM91A1-low versus FAM91A1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM91A1→partner) and Y-score (partner→FAM91A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FN1 →	+3.602	+4.851	.002	.002	1	4
BLOOD_Leukemia	GABRA1 →	+3.665	+2.823	.008	.008	1	4
LARGE_INTESTINE	FBXO7 →	+3.439	+3.693	<.001	<.001	1	3
BLOOD_Leukemia	IL2RB →	+4.665	+3.157	.003	.003	1	3
LARGE_INTESTINE	PRUNE2 →	+1.931	+3.280	<.001	<.001	1	3
LARGE_INTESTINE	INTS2 →	+2.146	+2.321	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,579 associations by consensus.

FN1 by FAM91A1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →