FAM8A1

Across TCGA pan-cancer cohorts, FAM8A1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FAM8A1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher FAM8A1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FAM8A1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where FAM8A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.607	1.000	.010	19	view →
HNSC	OS	Median	All	0.484	1.000	.038	6	view →
LUAD	OS	Median	III,IV	0.743	0.324	.021	4	view →
PDAC	DFS	Median	II,III,IV	0.482	0.325	.041	2	view →
LSCC	DFS	Tertile	II,III,IV	0.825	0.307	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FAM8A1–CCRCC (OS)

Open the CCRCC breakdown →