FAM8A1

Across TCGA pan-cancer cohorts, FAM8A1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FAM8A1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where FAM8A1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types FAM8A1 is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

LUAD, COAD, and PDAC are the cancer types where FAM8A1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM8A1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.404	<.001	9	view →
COAD	All	All	−0.639	<.001	7	view →
PDAC	Male	All	−0.749	<.001	6	view →
OV	All	All	−0.688	.048	2	view →
LSCC	Female	All	−0.132	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

FAM8A1–LUAD

Open the LUAD breakdown →