FAM8A1

Across TCGA patient cohorts, FAM8A1 mutation is significantly associated with the RNA expression of many other genes, with 677 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM8A1-associated genes across cancer lineages are RNU5A-5P, RAB28P1, and SVOPL. Each is linked with FAM8A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM8A1-to-partner and partner-to-FAM8A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU5A-5P grouped by FAM8A1-low versus FAM8A1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM8A1→partner) and Y-score (partner→FAM8A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU5A-5P →	+0.566	+5.798	<.001	.003	3	2
SKCM	RAB28P1 →	+0.074	+7.816	<.001	.008	3	1
UCEC	SVOPL →	-0.422	-3.435	.004	.005	3	1
UCEC	C12orf43 →	+0.373	+3.354	.003	.005	3	1
UCEC	SLAMF8 →	+0.950	+3.338	.003	.005	3	1
UCEC	MRPL10 →	+0.472	+3.595	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 677 associations by consensus.

RNU5A-5P by FAM8A1 expression — LUAD

Explore this box plot interactively →