FAM8A1

Across TCGA patient cohorts, FAM8A1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM8A1-associated genes across cancer lineages are C-Raf, FoxM1, and JNK2. Each is linked with FAM8A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM8A1-to-partner and partner-to-FAM8A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by FAM8A1-low versus FAM8A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM8A1→partner) and Y-score (partner→FAM8A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.220	+2.321	.002	.035	3	2
UCEC	FoxM1 →	+0.295	+3.459	.023	.005	3	1
UCEC	JNK2 →	+0.222	+2.321	.026	.035	3	1
UCEC	Ku80 →	+0.340	+3.472	.004	.002	3	1
UCEC	MEK1 →	+0.378	+3.169	.039	.019	3	1
UCEC	STAT3_pY705 →	-0.502	-3.169	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

C-Raf by FAM8A1 expression — UCEC

Explore this box plot interactively →