FAM8A1

Across TCGA cell cohorts, FAM8A1 mutation is significantly associated with the RNA expression of many other genes, with 129 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM8A1-associated genes across cancer lineages are TMEM213, TGM7, and RHBDL1. Each is linked with FAM8A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM8A1-to-partner and partner-to-FAM8A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM213 grouped by FAM8A1-low versus FAM8A1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM8A1→partner) and Y-score (partner→FAM8A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM213 →	+0.063	+4.491	.001	<.001	3	2
URINARY_TRACT	TGM7 →	+0.013	+5.087	<.001	.004	3	1
LARGE_INTESTINE	RHBDL1 →	+0.914	+3.212	.004	.006	3	1
LARGE_INTESTINE	CTH →	+1.516	+3.212	<.001	.006	3	1
LARGE_INTESTINE	SLAMF1 →	+0.037	+2.748	.007	.004	3	1
LARGE_INTESTINE	GALR3 →	+0.073	+3.212	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 129 associations by consensus.

TMEM213 by FAM8A1 expression — BLOOD_Leukemia

Explore this box plot interactively →